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Improving the screening and treatment of hypertension in people living with HIV: An evidence-based policy brief by Malawi’s Knowledge Translation Platform

Collins Mitambo1,2, Shiraz Khan3, Beatrice L. Matanje-Mwagomba4, Chiyembekezo Kachimanga5, Emily Wroe5–7, Dalitso Segula8, Alemayehu Amberbir9,10, Daniela Garone10, Peter R.A. Malik10,11, Austrida Gondwe10, Josh Berman10

1. Directorate of Research, Ministry of Health, Lilongwe, Malawi

2. Public Health Institute of Malawi, Lilongwe, Malawi

3. UNC Project–Malawi, Lilongwe, Malawi

4. Directorate of Clinical Services, Ministry of Health, Lilongwe, Malawi

5. Abwenzi Pa Za Umoyo, Neno, Malawi

6. Partners in Health, Boston, Massachusetts, USA

7. Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

8. Malawi–Liverpool–Wellcome Trust Clinical Research Programme, Blantyre, Malawi

9. Malawi Epidemiology and Intervention Research Unit (MEIRU), Lilongwe, Malawi

10. Dignitas International, Zomba, Malawi

11. Faculty of Health Sciences and McMaster Health Forum, McMaster University, Hamilton, Ontario, Canada

Correspondence: Dr Collins Mitambo (

Key messages

The problem:

High burden of undiagnosed and untreated hypertension in people living with HIV in Malawi.

There is high and increasing burden of hypertension in Malawi in the general population and specifically among people living with HIV.1,2 In Malawi, 32% of the adult population have been found to be hypertensive; 94% of these patients are unaware and therefore untreated.3 In a small HIV-infected cohort in Blantyre, 46% of patients were found to have elevated blood pressure.4 The lack of a well organised and funded national hypertension screening and treatment programme leaves hypertension in patients poorly managed.

Policy options:

Integration of hypertension management into the well-established HIV programme

The first three proposed options should be considered mutually exclusive, while the fourth is a complimentary option that can supplement the facility-based options outlined in options one through three:

Integration of hypertension management into well-established HIV programmes; this will involve hypertension screening and treatment by the same health workers at Antiretroviral Treatment (ART) clinics.

Hypertension screening within HIV clinics and subsequent referral to other chronic care management services within the same clinic or other facility.

Development of a comprehensive chronic care clinic model; this suggests a new health system arrangement where multiple Noncommunicable Diseases (NCDs) and HIV chronic care are combined and offered at one point of care delivered by the same health workers.

The addition of hypertension screening and referral into community-based HIV activities; this option refers to community based activities aimed at capturing undiagnosed HIV infected and hypertensive patients and linking them to appropriate care.


• Description of a health system problem

• Viable options for addressing this problem

• Strategies for implementing these options

Not included: recommendations

• This policy brief does not make recommendations regarding which policy option to choose

Who is this policy brief for?

Policymakers, their support staff, and other stakeholders with an interest in the problem addressed by this policy brief

Why was this policy brief prepared?

To inform deliberations about health policies and programmes by summarising the best available evidence about the problem and viable solutions

What is an evidence-based policy brief?

Evidence-based policy briefs bring together global research evidence (from systematic reviews* where possible) and local evidence to inform deliberations about health policies and programmes *Systematic review: A summary of studies addressing a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise the relevant research, and to collect and analyse data from this research

Executive Summary The evidence presented in this executive summary is summarized from a full evidnece brief for policy.

The evidence for all four options is limited and the costs and cost-effectiveness of the four options are uncertain. Given the limitations of the currently available evidence, rigorous evaluation and monitoring of resource use and activities is warranted.

Implementation considerations:

A combination of strategies is likely needed to effectively implement hypertension care within Malawi’s HIV infected population

Several key enablers should be taken into account: recognition of the NCD epidemic, well established national HIV services and existing HIV and NCD guidelines.

Several barriers may jeopardize effective implementation of hypertension/HIV programs and will need to be actively addressed. This includes effects of HIV stigma, lack of health worker training, vertical HIV and NCD policies with limited collaboration, and finance as well as infrastructure development limitations. Strategies are suggested to mitigate these barriers within the full text.

The problem

There exists a high burden of undiagnosed and untreated hypertension within Malawi’s HIV infected population. Africa is facing a growing double burden of communicable and noncommunicable diseases. It is projected that by 2025 nearly three-quarters of people with hypertension will be living in developing countries.1,5 Hypertension is expected to lead to more deaths in Africa than infectious diseases in the next 20-30 years.6,7 Malawi is facing a high prevalence of hypertension in the general population.3 Whilst only limited data exists, the burden of hypertension in Malawi in people living with HIV appears to be at least as common as in the general population.4

Size of the problem

In African adults, the rate of hypertension is reported to exceed 25% in many settings. According to the STEPs survey, around one third of Malawian adults were reported to have hypertension in 2009: often this was undiagnosed and therefore untreated.3 The burden of hypertension is likely to increase due to population transition effects, related to urbanization, increases in life expectancy, increasing wealth and associated dietary and life-style changes.2 Linkages between some NCDs and infectious diseases including HIV have also been noted. A small study from Blantyre estimated that 46% of people living with HIV had elevated blood pressure.4

Factors underlying the problem

Several factors impact on the problem of hypertension in people living with HIV:

Organization and delivery arrangement

Malawi lacks a well-established national hypertension screening or treatment programme. Reliable diagnostic equipment and basic hypertensive medication are often not available in health centres. HIV and NCD programs are vertical with little or no integration.

Patients and providers

There is a limited training and mentorship available to health workers on the importance of screening for hypertension and its management. Malawi’s HIV program has clinics that often are only treating HIV. The providers at these clinics are consistently overburdened. Hypertension diagnosis and treatment awareness among people living with HIV is also low.

Financing arrangements

Funding mechanisms may play an underlying role in affecting the problem as vertical HIV and ART clinics are well funded with no encouragement to manage hypertension.

Four policy options

As has been described elsewhere,8 multiple Communities of Practice were developed during the formation of KTPMalawi, including a committee to improve the screening and treatment of hypertension within HIV-infected populations. Each Community of Practice’s mandate is to gather and synthesize the best available global and local evidence and produce evidence briefs for policy that have been used as the primary input into structured deliberative dialogues. The NCD-HIV Community of practice lays out below the best available local and global evidence on four policy options aimed at improving the active screening and management of hypertension among people living with HIV. The first three options described below are mutually exclusive, while the fourth can supplement the other health facility-based options.

Policy option 1: Integration of hypertension screening and treatment into existing HIV clinic structures

This policy option involves integrating hypertension screening and care into existing HIV services. All people living with HIV who are regularly seen by pre-ART or ART providers would be routinely screened and treated for hypertension.

HIV care has been proposed to provide a good opportunity for hypertension management.

From a health services perspective, chronic HIV infection and hypertension pose very similar challenges, as they both need long life treatment, regular monitoring and a reliable drug supply chain. Hypertension and HIV are also both diagnosed through simple screening tests and involve similar models of care.9

A search using multiple key words and databases as well as correspondence with experts in the field yielded no systematic reviews that discussed patient outcomes from the integration of hypertension and HIV screening and treatment. There is some evidence that specific NCDs may benefit from the strong systems already in place for HIV programs.10,11 A study from Ethiopia found that when HIV-specific standard operating protocols and provider support tools were adapted to NCD care, documentation improved dramatically.12 Several studies from Uganda, Tanzania, and Kenya that have found high levels of hypertension within HIV cohorts have argued for integrating screening and treatment within HIV clinics.13–15

Integration of care into one consultation may decrease costs to patients to access services,16 and may decrease health system costs by avoiding duplication but there is no strong evidence in support of this suggestion. There are likely to be upfront costs to integrating HIV and hypertension care and treatment which may include the development of support tools, training or re-training of the health workers, the provision of the requisite clinical equipment and consistent drug supplies.17

Policy option 2: Hypertension screening within HIV clinics and subsequent referral

People living with HIV could be screened for hypertension at pre-ART or ART clinics. Patients found to be hypertensive would then be referred to a general outpatient clinic or NCD clinic within the same health facility or other facilities if necessary for further management. Patients who are normotensive could be screened at regular intervals and could receive health lifestyle advice. This option allows for identification of undiagnosed hypertension among people living with HIV with referral to the appropriate clinical care.

There is limited documentation of programs integrating screening for hypertension and subsequent referral into HIV care models.13 In Neno District, Malawi, a pilot project has integrated hypertension screening into community and clinic based HIV activities.18,19 Early results show that this health system arrangement is feasible, however linkage to care is poor: 12% of community-screened patients were referred for hypertension management but only 20-25% of these referrals were enrolled in the NCD clinic.

Govindasamy et al. looked at screening for NCDs including hypertension during mobile HIV-testing campaigns in South Africa.20 The authors found 58.1% of the participants had elevated blood pressure and 50% of them linked to care.

There is need for more implementation research and piloting of this model of care to produce evidence of the possible advantages and disadvantages associated with screening and referral.

MMJ-2016-11-0159.R1_Malick PF_Table 1_170627.pages

Policy Option 3: Development of a comprehensive chronic care clinic model

This policy option suggests a new model of care where multiple NCDs and HIV chronic care are merged into one chronic care clinic with all chronic conditions managed by the same healthcare worker.

In Malawi, there are some Chronic Care Clinic (CCC) models being piloted but only one site, in Neno, has included HIV in their CCC model.19 In Neno District, pre-existing ART clinics, which were functional at all 13 health facilities, were converted to a CCC model where patients with HIV and/or an NCD diagnosis (most commonly hypertension, asthma, epilepsy, diabetes, and heart failure) are seen for all of their conditions in one combined visit. Patients are also screened for comorbid conditions at the clinic. Implementation was completed in the first half of 2015 with early results expected late in the year.

The integrated NCD clinic at Kasungu District Hospital for instance, saw a > 100% rise in the size of the hypertension cohort and > 200% rise in the size of the diabetes patient cohorts between July 2012 and December 2013 (unpublished NCD program report, presented at MOH midyear review; April 2014). However, this NCD clinic has not integrated HIV services.21 In 2013 an integrated electronic medical record system for chronic NCDs including hypertension, diabetes, asthma and epilepsy, together with HIV was developed and is currently being piloted at two sites in Malawi.

A literature search found a few “lessons learned” papers, of which only one described a health system arrangement where HIV care has been integrated into a chronic care clinic model in Cambodia.22 The Cambodia CCC integrated care for HIV, hypertension and diabetes as well as epilepsy and thyroid disorders. Physicians and nurses received training in principles of chronic disease management and counsellors provided “a series of activities complementary to the medical consultations”. There were “satisfactory outcomes” for all groups and importantly the authors noted that there was acceptability of the integrated model from both HIV and non-HIV patients.

There is need for more implementation research and piloting of this model of care to produce evidence of the possible advantages and disadvantages associated with chronic care clinics that incorporate HIV.

Policy option 4: The addition of hypertension screening and referral into comunity-based HIV activities

This policy option lays out a public health approach to capture undiagnosed HIV-infected and hypertensive patients and link them to appropriate health services. Both diseases can be screened for within community settings at low cost. In resource-limited settings, where health-seeking behavior is often poor and where there is limited access to quality chronic disease management, community based screening and referral to care may serve as an effective point of entry to care.

Although the Malawi HIV programme has several community-based activities that have been successful in improving HIV testing rates and supporting linkages to care, these national HIV community-screening activities have not been integrated with hypertension or any other disease screening effort.23

Community-based screening for multiple NCDs including hypertension and HIV has been shown to be feasible in one study in Kenya.24 Importantly, an informal survey of the counselors at the end of home-based screening revealed that participants who were initially reluctant to undergo HIV testing were more likely to be tested if they were offered screening for diabetes or hypertension at the same time. A study conducted in rural Uganda and Cape Town25 found that a community campaign with an integrated screening approach for multiple communicable and NCDs including hypertension, HIV, diabetes and malaria were feasible and highly accepted. However, this study showed that linkages to care after an elevated blood pressure diagnoses were sub-optimal. This study showed that active case detection in the community can contribute to early hypertension treatment and care but promoting linkages to care must be continually addressed.

Implementation considerations

Employing any one of these policy options would necessitate significant changes in other areas of the health system that must be examined and planned for. Implementation strategies can capitalize on enablers of these policy options to improve the screening and treatment of hypertension among people living with HIV as well as addressing barriers to doing so.

Key enablers to improve the screening and treatment of hypertension among HIV infected patients include:

Global recognition of the NCD epidemic in developing countries

Emerging local evidence of the magnitude of the problem

Well established HIV services at tertiary, district and primary-care levels

Existing national guidelines for the management of chronic conditions including hypertension

Inclusion of NCDs in Malawi’s essential health package

The rapid progress of Malawi NCD program and emerging NCD policies

Evidence regarding barriers to improving the screening and treatment of hypertension among people living with HIV and strategies to address these barriers are summarised in Table 1.

Next Steps

The aim of this policy brief is to foster dialogue and judgements that are informed by the best available evidence. The intention is not to advocate specific options or close off discussion. Further actions will flow from the deliberations that the policy brief is intended to inform. These might include:

The need for further research on each of these policy options. Pilot programs could be developed in selected locations within Malawi and closely studied to elucidate patient outcomes, cost-effectiveness and unintended consequences.

Development of clear guidance or policy on hypertension screening and treatment of HIV infected patients.


This policy brief was prepared with the aid of a grant from the International Development Research Centre, Ottawa, Canada, the Health Research Capacity Strengthening Initiative (HRCSI) hosted by the Malawi National Commission for Science and Technology, Grand Challenges Canada and USAID-Malawi.We would like to thank the following people for providing us with input and feedback:

Dr. Joep van Oosterhout

Caitlyn Timmings

Dr. Julia Moore

Prof Shabbar Jaffar

Dr. Mia Crampin

Dr. Damson Kathyola

Dr. Lonia Mwape

Dr. Martha Masamba

Dr. Lisa Puchalski Ritchie

KTPMalawi Steering Committee members

Competing interests

None of the authors reported a conflict of interest

This policy brief was prepared by Malawi’s Knowledge Translation Platform’s Noncommunicable disease – HIV Community of Practice, under the EVIPNet programme.

The Evidence-Informed Policy Network (EVIPNet) promotes the use of health research in policymaking. Focusing on low- and middle-income countries, EVIPNet promotes partnerships at the country level between policymakers, researchers and civil society in order to facilitate policy development and implementation through the use of the best scientific evidence available.


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