{"id":11283,"date":"2021-03-03T10:35:11","date_gmt":"2021-03-03T10:35:11","guid":{"rendered":"https:\/\/www.mmj.mw\/?p=11283"},"modified":"2021-03-18T07:12:50","modified_gmt":"2021-03-18T07:12:50","slug":"serological-survey-and-risk-factors-associated-with-toxoplasma-gondii-infection-among-hiv-infected-pregnant-women-attending-abuja-tertiary-hospital-nigeria","status":"publish","type":"post","link":"https:\/\/www.mmj.mw\/?p=11283","title":{"rendered":"Original Research: Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria"},"content":{"rendered":"\n<p><strong>Maryam Zakari<\/strong> <\/p>\n\n\n\n<p>Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria<\/p>\n\n\n\n<p><strong>Keywords:&nbsp;<\/strong>Toxoplasmosis, HIV coinfection, congenital anomaly, cellular immunity, sero-survey<\/p>\n\n\n\n<h3>Abstract<\/h3>\n\n\n\n<p><strong>Background<\/strong><br>Toxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to inform clinicians about the significance of maternal toxoplasmosis in antenatal care.<br><strong>Aim<\/strong><br>This study aimed to determine the seroprevalence of Toxoplasma gondii infection, associated CD4+ T-cell profile and sociodemographic risk factors among pregnant women with or without HIV infection attending the University of Abuja Teaching Hospital, Abuja, Nigeria.<br><strong>Methods<\/strong><br>This hospital-based cross-sectional study involved blood samples collected from 160 HIV-infected and 160 HIV-seronegative pregnant women. These samples were analysed for anti-T. gondii (IgG and IgM) and CD4+ T-cell count using ELISA and flow cytometry, respectively. Sociodemographic variables of participants were collected using structured questionnaires.<br><strong>Results<\/strong><br>The overall seroprevalence of anti-T. gondii IgG and IgM was 28.8% and 3.8%, respectively. The seroprevalence of anti-T. gondii IgG and IgM was 29.4% and 4.4%, respectively, among HIV-seropositive pregnant women and 28.1% and 3.1%, respectively, among HIV-seronegative women. There was no significant association between the seroprevalence of anti-T. gondii-IgG and anti-T. gondii-IgM with age, gestational age, education level, parity or place of residence of HIV-infected pregnant women (P &gt; 0.05). However, there was significant association between the seroprevalence of anti-T. gondii-IgG (P = 0.03) and anti-T. gondii-IgM (P = 0.01) with education level. CD4+ T-cell count varied significantly between HIV-infected and HIV-uninfected pregnant women (P = 0.035).<br><strong>Conclusion<\/strong><br>In this study, the seroprevalence of anti-T. gondii IgG and IgM did not differ in HIV-seropositive or HIV-seronegative pregnant women. However, women with primary T. gondii and HIV coinfection had lower CD4+ T-cell count than those with toxoplasmosis monoinfection.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2>Journal Identifiers<\/h2>\n\n\n\n<p>eISSN: 1995-7262<br>print ISSN: 1995-7262<\/p>\n\n\n\n<div class=\"wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/www.mmj.mw\/wp-content\/uploads\/2021\/03\/201128-Article-Text-504329-1-10-20201030.pdf\">Download PDF<\/a><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maryam Zakari Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria Keywords:&nbsp;Toxoplasmosis, HIV coinfection, congenital anomaly, cellular immunity, sero-survey Abstract BackgroundToxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[72],"tags":[66,88],"_links":{"self":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/11283"}],"collection":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11283"}],"version-history":[{"count":2,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/11283\/revisions"}],"predecessor-version":[{"id":11507,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/11283\/revisions\/11507"}],"wp:attachment":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}