{"id":12858,"date":"2023-10-09T13:52:47","date_gmt":"2023-10-09T13:52:47","guid":{"rendered":"https:\/\/www.mmj.mw\/?p=12858"},"modified":"2023-10-11T08:12:56","modified_gmt":"2023-10-11T08:12:56","slug":"ferritin-lymphocyte-percentage-ratio-to-predict-the-severity-and-mortality-of-covid-19","status":"publish","type":"post","link":"https:\/\/www.mmj.mw\/?p=12858","title":{"rendered":"Ferritin\/lymphocyte percentage ratio to predict the severity and mortality of COVID-19"},"content":{"rendered":"\n

Nur SIMSEK YURT1<\/sup>, Metin OCAK2<\/sup><\/strong><\/p>\n\n\n\n

  1. Clinic of Family Medicine, Samsun Training and Research Hospital, Samsun, Turkey<\/li>
  2. Clinic of Emergency Medicine, Samsun Gazi State Hospital, Samsun, Turkey<\/li><\/ol>\n\n\n\n

    Corresponding Author: Nur SIMSEK YURT<\/strong>; Email: nursimsekyurt@gmail.com<\/p>\n\n\n\n

    Abstract
    Objective<\/strong>
    In this study, we aimed to investigate the relationship between ferritin\/lymphocyte percentage ratio (FLPR) with clinical and radiological disease severity and mortality in COVID-19 patients.
    Methods<\/strong>
    This retrospective study was conducted with patients who had polymerase chain reaction positive results for COVID-19. We calculated FLPRs from laboratory tests taken during emergency clinic admission. The relationship between chest computed tomography (CT) scores, disease severity, and 30-day mortality with FLPR was evaluated.
    Results<\/strong>
    Our study included 309 patients. 30-day mortality occurred in 12.3% (n=38) of the patients. A statistically significant association was found between FLPR and clinical disease severity (p <0.001). In the post hoc analysis, the difference was caused by the critical and severe groups and FLPR was significantly higher in these groups. A significant correlation was found between CT scores and FLPR (r=0.496, p<0.001). Logistic regression analysis revealed that hypertension, smoking, C-reactive protein (CRP), and FLPR levels were independent risk factors for mortality in COVID-19 patients. In the receiver operating characteristics curve analysis, determined the predictive value and the optimal cut-off value of FLPR. The areas under the curve of WBC, lymphocyte, neutrophil, ferritin, CRP, FLPR were found 0.707, 0.233, 0.735, 0.878, 0.831, 0.924 (p<0.001), respectively. This analysis showed that the FLPR can predict 30-day mortality better than the other biomarkers in the comparison. When the optimal cut-off value of FLPR is 42.4, the sensitivity is 84.2% and specificity is 86.7%.
    Conclusion<\/strong>
    FLPR can be used as an independent biomarker of disease severity and mortality in COVID-19
    .
    Key words:<\/strong> COVID-19, ferritin\/lymphocyte percentage ratio, inflammation, mortality, disease severity, predictive value<\/p>\n\n\n\n

    \n
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    Nur SIMSEK YURT1, Metin OCAK2 Clinic of Family Medicine, Samsun Training and Research Hospital, Samsun, Turkey Clinic of Emergency Medicine, Samsun Gazi State Hospital, Samsun, Turkey Corresponding Author: Nur SIMSEK YURT; Email: nursimsekyurt@gmail.com AbstractObjectiveIn this study, we aimed to investigate the relationship between ferritin\/lymphocyte percentage ratio (FLPR) with clinical and radiological disease severity and mortality […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[125],"tags":[66],"_links":{"self":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/12858"}],"collection":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12858"}],"version-history":[{"count":2,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/12858\/revisions"}],"predecessor-version":[{"id":12883,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/12858\/revisions\/12883"}],"wp:attachment":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}