{"id":13250,"date":"2025-01-13T13:44:28","date_gmt":"2025-01-13T13:44:28","guid":{"rendered":"https:\/\/www.mmj.mw\/?p=13250"},"modified":"2025-01-13T13:44:29","modified_gmt":"2025-01-13T13:44:29","slug":"antipsychotic-medication-non-adherence-and-its-determinants-among-out-patients-with-schizophrenia","status":"publish","type":"post","link":"https:\/\/www.mmj.mw\/?p=13250","title":{"rendered":"Antipsychotic medication non-adherence and its determinants among out-patients with schizophrenia"},"content":{"rendered":"\n

Paul Erohubie1<\/sup>, Sunday Oriji2<\/sup>*, Sunday Olotu3<\/sup>, Imafidon Agbonile4<\/sup>, Ihechiluru Anozie5<\/sup>, Omigie Erohubie6<\/sup>, Anthony Enebe7<\/sup>, Justus Onu8<\/sup><\/strong><\/p>\n\n\n\n

  1. Irrua Specialist Teaching Hospital Ringgold standard institution – Department of Psychiatry Irrua, Edo State, Nigeria<\/li>
  2. Nnamdi Azikiwe University Ringgold standard institution – Department of Mental Health, Nnewi campus, Nnewi, Anambra, Nigeria<\/li>
  3. Federal Neuro Psychiatric Hospital Ringgold standard institution – Clinical services, Benin City, Edo State, Nigeria<\/li>
  4. Federal Neuro Psychiatric Hospital Ringgold standard institution – clinical services Benin City, Edo State, Nigeria<\/li>
  5. Federal Neuro Psychiatric Hospital Ringgold standard institution – clinical services, Benin City, Edo State, Nigeria<\/li>
  6. Edo State University Uzairue Ringgold standard institution – Department of Radiology, Iyamho, Edo State, Nigeria<\/li>
  7. Federal Medical Centre Asaba Ringgold standard institution – psychiatry, Asaba, Delta State, Nigeria<\/li>
  8. Nnamdi Azikiwe University Ringgold standard institution – Department of Mental Health, Nnewi Campus, Nnewi, Anambra, Nigeria<\/li><\/ol>\n\n\n\n

    *Corresponding Author<\/strong>: Sunday Oriji; E-mail<\/strong>: orijisunday@gmail.com<\/p>\n\n\n\n

    Abstract
    Introduction<\/strong>
    While antipsychotics are key requirement in acute and long-term management of schizophrenia, medication adherence remains a major unmet need in its care. This paper assessed the prevalence of oral antipsychotic non-adherence among outpatients with schizophrenia and its associated clinico-demographic factors.
    Method<\/strong>
    Three hundred and ten adult outpatients (18-64 years of age) were cross-sectionally interviewed after being diagnosed of schizophrenia using ICD-10 criteria, and the diagnosis confirmed with the Mini International Neuropsychiatric Interview (MINI). The socio-demographic questionnaire, Morisky Medication Adherence scale (MMAS-8), Brief Psychiatric Rating Scale (BPRS), Liverpool University Neuroleptic Side Effects Scale (LUNSERS), Drug Attitude Inventory (DAI-10), Scale to Assess Unawareness of Mental Disorders (SUMD) were used to obtain participants\u2019 demographic profile, level of medication adherence, illness severity, attitude towards antipsychotics, and level of insight respectively.
    Results<\/strong>
    At least one in every two outpatients with schizophrenia (n=158; 51.0%) did not adhere to their antipsychotics as prescribed. The independent risk factors for poor oral antipsychotic adherence were illness severity (p= 0.001; AOR 1.13), psychoactive substance use (p= 0.009; AOR 1.87), young age (p= 0.014; AOR 2.09), perceived poor social support (p= 0.025; AOR 3.58), use of first generation antipsychotics alone (p= 0.006; AOR 17.99), use of second generation antipsychotics alone (p= 0.02; AOR 29.36), and awareness of symptoms (p= 0.025; AOR 1.18).
    Conclusion<\/strong>
    The high rate of poor medication adherence should necessitate much emphasis on the highlighted modifiable risk factors and the need for continuous adherence assessments and education in clinical practice.
    Keywords:<\/strong> Antipsychotics, adherence, determinants, schizophrenia, Nigeria<\/p>\n\n\n\n

    \n
    DOWNLOAD PDF<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Paul Erohubie1, Sunday Oriji2*, Sunday Olotu3, Imafidon Agbonile4, Ihechiluru Anozie5, Omigie Erohubie6, Anthony Enebe7, Justus Onu8 Irrua Specialist Teaching Hospital Ringgold standard institution – Department of Psychiatry Irrua, Edo State, Nigeria Nnamdi Azikiwe University Ringgold standard institution – Department of Mental Health, Nnewi campus, Nnewi, Anambra, Nigeria Federal Neuro Psychiatric Hospital Ringgold standard institution – […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[131],"tags":[66],"_links":{"self":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13250"}],"collection":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13250"}],"version-history":[{"count":1,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13250\/revisions"}],"predecessor-version":[{"id":13251,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13250\/revisions\/13251"}],"wp:attachment":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}