{"id":13341,"date":"2025-04-02T10:04:42","date_gmt":"2025-04-02T10:04:42","guid":{"rendered":"https:\/\/www.mmj.mw\/?p=13341"},"modified":"2025-04-02T10:05:59","modified_gmt":"2025-04-02T10:05:59","slug":"assessment-of-diagnostic-efficacy-high-fluorescent-cells-combined-with-cea-nse-and-cyfra21-1-in-malignant-pleural-effusion-identification","status":"publish","type":"post","link":"https:\/\/www.mmj.mw\/?p=13341","title":{"rendered":"Assessment of diagnostic efficacy: High fluorescent cells combined with CEA, NSE, and Cyfra21-1 in Malignant Pleural Effusion Identification"},"content":{"rendered":"\n

Ning Zhang1<\/sup>, Thomas Stuart Mughogho2<\/sup>, Aubrey Nothale2<\/sup>, Dokani Michael Ndovi2<\/sup>, Rashid Kaseka2<\/sup>, Zhonglin Wang1<\/sup>, Jian Hu1<\/sup>, Jie Zheng3<\/sup>, <\/em>Xiaoqin Wang1<\/sup>,<\/em><\/strong>*<\/sup><\/p>\n\n\n\n

  1. Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li>
  2. Laboratory Department, Mzuzu Central Hospital, Private Bag 209, Luwinga, Mzuzu 2, Malawi<\/li>
  3. Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li><\/ol>\n\n\n\n

    Co-corresponding authors<\/strong>: Jie Zheng; Email:jiezheng@xjtu.edu.cn, Xiaoqin Wang; Email: <\/strong>wxq1493722680@xjtufh.edu.cn, These authors jointly supervised this work<\/p>\n\n\n\n

    Abstract
    Objective<\/strong>
    To determine routine and biochemical parameters, as well as tumor markers, that are significantly different between malignant pleural effusion (MPE) and benign pleural effusion (BPE), and to evaluate the diagnostic efficacy of the combination of routine and biochemical parameters, along with carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragment (Cyfra21-1) measurements in pleural effusion for identifying MPE.
    Methods<\/strong>
    1,238 patients with pleural effusion from the First Affiliated Hospital of Xi\u2019an Jiaotong University were recruited and categorized into two groups: MPE (n = 397) and BPE (n = 841). Biomarker levels were compared, and receiver operating characteristic (ROC) curves were performed on the statistically significant indicators to assess the diagnostic efficacy for MPE.
    Results<\/strong>
    High-Fluorescent cells (HFC), CEA, NSE, and Cyfra21-1 were significantly elevated in MPE (P < 0.001) and positively correlated with its presence (P < 0.001). The area under the curve (AUC), cutoff value, sensitivity, and specificity were: [0.726 (95% CI: 0.696-0.756), 17.5, 8.5%, 57.4%]; [0.894 (95% CI: 0.873-0.914), 5.78, 80.7%, 88.6%]; [0.703(95% CI: 0.672-0.735), 10.97, 59.3%, 71.9%] and [0.774 (95% CI: 0.746-0.802), 34.61, 74.7%, 67.9%], respectively. When focusing on multi-biomarker strategy, the combination of HFC and CEA offered the highest diagnostic efficiency (AUC: 0.868; 95% CI: 0.847-0.889), with a sensitivity of 88.4% and a specificity of 70.7%.
    Conclusion<\/strong>
    HFC, CEA, NSE, and Cyfra21-1 are valuable diagnostic markers for MPE, with optimal cutoff values of 17.5 \u00d7 106\/L, 5.78 ng\/mL, 10.97 ng\/mL, and 34.61 ng\/mL, respectively. The HFC+CEA combinations enhanced diagnostic sensitivity and clinical utility.<\/p>\n\n\n\n

    Keywords<\/strong>: Malignant pleural effusion,High-fluorescent cells, CEA, NSE, Cyfra21-1<\/p>\n\n\n\n

    \n
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    Ning Zhang1, Thomas Stuart Mughogho2, Aubrey Nothale2, Dokani Michael Ndovi2, Rashid Kaseka2, Zhonglin Wang1, Jian Hu1, Jie Zheng3, Xiaoqin Wang1,* Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China Laboratory Department, Mzuzu Central Hospital, Private Bag 209, Luwinga, Mzuzu 2, Malawi Department of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[134],"tags":[66],"_links":{"self":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13341"}],"collection":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13341"}],"version-history":[{"count":1,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13341\/revisions"}],"predecessor-version":[{"id":13342,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13341\/revisions\/13342"}],"wp:attachment":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}