{"id":13490,"date":"2025-09-15T09:12:20","date_gmt":"2025-09-15T09:12:20","guid":{"rendered":"https:\/\/www.mmj.mw\/?p=13490"},"modified":"2025-09-15T09:12:22","modified_gmt":"2025-09-15T09:12:22","slug":"effect-of-hepatitis-c-virus-infection-on-liver-function-t-cell-immunity-and-mortality-risk-in-maintenance-hemodialysis-patients","status":"publish","type":"post","link":"https:\/\/www.mmj.mw\/?p=13490","title":{"rendered":"Effect of Hepatitis C Virus Infection on Liver Function, T Cell Immunity, and Mortality Risk in Maintenance Hemodialysis Patients"},"content":{"rendered":"\n

Ning Zhang1,#<\/sup>, Hua Liu2,#<\/sup>, Syleenah Molebogeng Moloto3<\/sup>, Jian Hu1<\/sup>, Jie Zheng4<\/sup>, Yingli He5<\/sup>, Xiaoqin Wang1<\/sup><\/em><\/strong><\/p>\n\n\n\n

  1. Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li>
  2. Department of Blood Purification, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li>
  3. Health Science Center, Xi\u2019an Jiaotong University, 76# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li>
  4. Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li>
  5. Department of Infectious Diseases, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China<\/li><\/ol>\n\n\n\n
    Both authors are co-first authors and have contributed equally to this work.<\/h6>\n\n\n\n

    *Corresponding Authors<\/strong>: Yingli He; Email: heyingli2000@xjtu.edu.cn; Xiaoqin Wang; Email: wxq1493722680@xjtufh.edu.cn<\/p>\n\n\n\n

    Abstract
    Objective<\/strong>
    This retrospective study explored the clinical impact of hepatitis C virus (HCV) infection in maintenance hemodialysis (MHD) patients through comprehensive analysis of liver\/renal function parameters, cellular immunity profiles, and long-term survival outcomes.
    Methods<\/strong>
    The study enrolled 28 HCV-infected MHD patients (MHD-HCV group), 28 HCV-negative MHD patients (MHD group), and 21 healthy controls (NC group) retrospectively. Liver and renal functions, lymphocyte subset analysis, and interleukin-10 (IL-10) levels were assessed. Overall survival at a median follow-up of 4 years was compared between the MHD-HCV and MHD groups.
    Results<\/strong>
    Biochemical analysis demonstrated significantly elevated liver enzymes in the MHD-HCV group compared to MHD group, with mean alanine aminotransferase (ALT) levels of 26.6 \u00b1 18.6 vs. 10.1 \u00b1 7.1U\/L (P < 0.001) and aspartate aminotransferase (AST) levels of 20.0 \u00b1 9.0 vs. 11.8 \u00b1 5.5U\/L (P = 0.001).Furthermore, the MHD-HCV group had elevated total bile acid (7.70 \u00b1 7.17 vs. 3.44 \u00b1 1.75, P = 0.007), total protein (67.9 \u00b1 5.2 vs. 63.9 \u00b1 5.6, P = 0.012), globulin (31.1 \u00b1 5.9 vs. 26.5 \u00b1 3.6, P = 0.003). Immunological profiling revealed significant upregulation of both regulatory T cells (Tregs: 4.48 \u00b1 2.94 vs. 2.48 \u00b1 1.81, P < 0.001) and interleukin-10 (IL-10: 78.7 \u00b1 45.1 vs. 34.2 \u00b1 15.2, P < 0.001).The patients in the MHD-HCV group had higher mortality risk compared with those in the MHD group (\u03c72=4.383, P = 0.036).
    Conclusion<\/strong>
    HCV infection in MHD patients leads to non-negligible liver dysfunction, elevated Tregs and IL-10, as well as higher mortality.<\/p>\n\n\n\n

    Keywords:<\/strong> Hepatitis C virus; maintenance hemodialysis; liver function; regulatory T cells; interleukin-10.<\/p>\n\n\n\n

    \n
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    Ning Zhang1,#, Hua Liu2,#, Syleenah Molebogeng Moloto3, Jian Hu1, Jie Zheng4, Yingli He5, Xiaoqin Wang1 Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi Province, China Department of Blood Purification, The First Affiliated Hospital of Xi\u2019an Jiaotong University, 277# West Yanta Road, Xi\u2019an, 710061, Shaanxi […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[137],"tags":[66],"_links":{"self":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13490"}],"collection":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13490"}],"version-history":[{"count":1,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13490\/revisions"}],"predecessor-version":[{"id":13491,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=\/wp\/v2\/posts\/13490\/revisions\/13491"}],"wp:attachment":[{"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mmj.mw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}