The beneficial effect of Adansonia digitata products success to modulate lipid profiles and inhibit LDL oxidation in-vitro: An associational study

Ahmed M. Ahmed1*, Omar F. Khabour2, Amjad Yousuf1, Saber M. Eweda1,3, Walaa Mohammedsaeed1, Haytham M. Daradka4, Salwa F. M. Hassanein5, Amna M. Ibrahim6

  1. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina 42353, Kingdom of Saudi Arabia.
  2. Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
  3. Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21561, Egypt.
  4. Department of Biology, Faculty of Science, Taibah University, Medina 42353, Kingdom of Saudi Arabia.
  5. Department of Food Science and Nutrition, Faculty of Family Sciences, Taibah University, Medina 42353, Kingdom of Saudi Arabia.
  6. Faculty of Medicine, Omdurman Islamic University, Khartoum, Sudan

*Corresponding Author: Ahmed M. Ahmed, Email;,


There is a growing interest in medicinal plants in recent years due to their many therapeutic benefits and low side effects. Among the medicinal plants is the African Adansonia digitata (baobab) that has edible fruit. In the current study, the effect of A. digitata juice consumption on the lipid profile was investigated. In addition, inhibition of the oxidation of low-density lipoprotein cholesterol (LDL-C) in-vitro by A. digitata essential oil (EO) was also investigated. Methods

In this cohort study, a total of 70 subjects of A. digitata users (AD group, 42 male and 28 female) and 70 non A. digitata users (Non-AD group, 44 male and 26 female) were recruited to participate in this study. We evaluated lipid profile, HbA1c, liver/kidney functions, and phytosterol contents in fasting blood samples of all participants.


The present findings illustrated significantly lower levels of total cholesterol, triglycerides, and LDL in the AD group compared to Non-AD (p < 0.01). In addition, essential oil of A. digitata inhibited LDL oxidation in-vitro as shown by the significant decreases in the formation of malonaldehyde (MDA), protein carbonyl (PC), and lipid hydroperoxide (LHP) (P<0.05). No significant changes in fasting blood glucose, HbA1c, HDL, kidney function, and liver function enzymes between the two groups were detected (P>0.05).


The juice of A. digitata has hypolipidemic and antioxidative effects and might be beneficial for the management of lipid levels in the body.

Keywords: Adansonia digitata, Baobab, lipid profile, lipid oxidation, essential oil

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