Gongjian Dai*
Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, China.
- Corresponding Author: Gongjian Dai; E-mail: dgj197472@126.com
Background
Colorectal cancer (CRC) is a common malignant tumor in the gastrointestinal tract. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are commonly used tumor markers for gastrointestinal tumors, and they have specific reference values for postoperative recurrence and metastasis. This study aimed to analyze the changes in CEA and CA19-9 levels in CRC patients and their relationship with survival rate and clinical outcomes.
Methods
This was a retrospectively study. The clinical data of 101 patients with advanced CRC who visited Jiangsu Cancer Hospital from August 2013 to October 2020 were selected. They were divided into 61 cases in A-D group (increasing first and then decreasing) and 40 cases in D-A group (decreasing first and then increasing) based on the changes in CEA and CA19-9 levels before and after chemotherapy. The clinical characteristics of the two groups were compared, and the correlation between the levels of CEA and CA19-9 and the overall survival rate and clinical efficacy of the patients were analyzed.
Results
Compared with the D-A group, the survival rate and progression-free survival rate (PFS) of patients in the A-D group were higher. The partial response rate (PR) of the A-D group was 60.7%, and the objective response rate (ORR) was 60.7%, both significantly higher than 32.5% and 32.5% of the D-A group; the disease progression rate (PD) of the A-D group was 11.5%, significantly lower than 35% of the D-A group, and the difference was statistically significant. There was no significant difference in the disease stability (SD) rate between the two groups.
Conclusions
The changes in CEA and CA19-9 levels before and after chemotherapy in advanced CRC patients are related to the prognosis and clinical efficacy of these patients, and can be used as key indicators for evaluating the prognosis of advanced CRC patients.
Keyword: colorectal cancer, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), overall survival